Keto Means
Keto Means
Photo: Ketut Subiyanto
No substantial effects of coffee or caffeine on fasting glucose concentrations were observed. The increased fasting insulin concentration after high coffee consumption in our study probably reflects decreased insulin sensitivity.
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Read More »The studies were approved by the TNO Nutrition and Food Research Medical Ethics Committee, and all participants gave informed consent. The trials were originally designed to study the effects of coffee and caffeine on plasma concentrations of homocysteine, and the study designs have been reported in detail previously ( 17 , 18 ). Participants were regular coffee consumers (more than five cups/day) and did not have known diabetes. The first study was a 4-week crossover study that compared the effects of regular paper-filtered coffee consumption with that of coffee abstinence. A total of 40 volunteers used 1 l of coffee (70 g coffee grounds) for 4 weeks and abstained from coffee for 4 weeks in random order. Fourteen participants did not complete the trial because of nausea and restlessness (n = 7), possible susceptibility to adverse effects of caffeine intake (n = 3), or reasons unrelated to treatment (n = 4). Thus, 26 participants were included in the analysis. The second study had a Latin-square design with three treatments given in random order for 2 weeks each: caffeine (a total of 870 mg in six capsules), regular paper-filtered coffee (52 g ground coffee/day in 0.9 l), and placebo (six capsules containing cellulose). Of the 54 volunteers, 6 subjects withdrew because of severe headaches (n = 2), study-related illness (n = 1), or reasons unrelated to treatment (n = 3). For the current analyses, we excluded participants because of missing blood samples (n = 1), not completing the whole caffeine intervention (n = 1), or who were clear outliers for an insulin concentration (n = 1). Thus, 45 subjects were included in the analysis. Caffeine-containing products (other than those provided) were prohibited during the entire trial. Venous blood samples were collected after an overnight fast. Plasma glucose concentrations were measured using the glucose hexokinase method. Serum insulin concentrations were measured using an immunoradiometric assay (Medgenix Biosource Diagnostics, Fleuris, Belgium).
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